Fenofibrate Monotherapy Induced Rhabdomyolysis

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Fenofibrate monotherapy-induced rhabdomyolysis in a patient with type-2 diabetes.

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OBSERVATIONS Simvastatin, Fenofibrate, and Rhabdomyolysis

The National Cholesterol Education Program (NCEP) guidelines recommend use of statin-fibrate combinations to treat combined dyslipidemia. Myopathy and rhabdomyolysis are reported side effects, especially with gemfibrozil-statin combinations (1). This risk is recognized to result from both pharmacodynamic and pharmacokinetic interactions. In vitro studies in human hepatocytes have shown that unl...

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Rhabdomyolysis associated with fenofibrate monotherapy is extremely rare. Here, we report a rare case of rhabdomyolysis of the psoas muscle in an 82-year-old man with chronic myelogenous leukemia (CML). He was prescribed fenofibrate because of a hypertriglyceridemia. The patient reported generalized muscle pain and right abdominal pain while receiving fenofibrate monotherapy. An abdominal compu...

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Acute renal failure due to fenofibrate monotherapy.

Rhabdomyolysis is a clinical and biochemical syndrome resulting from skeletal muscle injury and the release muscular cell constituents into extracellular fluid and the circulation (1). Rhabdomyolysis occurs due to drugs, toxins, ischemia and infections. Drug induced rhabdomyolysis mostly occurs with statins but rarely with fibrates. Fibrates are widely used for the treatment of hypertriglycerid...

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Rhabdomyolysis-Induced Acute Renal Failure Following Fenofibrate Therapy: A Case Report and Literature Review

Fenofibrate, a fibric acid derivative, is used to treat diabetic dyslipidemia, hypertriglyceridemia, and combined hyperlipidemia, administered alone or in combination with statins. Rhabdomyolysis is defined as a pathological condition involving skeletal muscle cell damage leading to the release of toxic intracellular material into circulation. Its major causes include muscle compression or over...

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ژورنال

عنوان ژورنال: Diabetes Care

سال: 2003

ISSN: 0149-5992,1935-5548

DOI: 10.2337/diacare.26.8.2482